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Application of Vathin Single-use electronic ureterorenoscopic catheter in the treatment of urinary calculi (RIRS)

2023-10-27

The most common pharmacologic treatments for urinary stones include extracorporeal shock wave lithotripsy, ureteroscopic lithotripsy for stone removal, and percutaneous nephrolithotripsy for stone removal. 。The success rate of surgical treatment depends on the surgeon's experience, the size, location, and composition of the stone, as well as the patient's specific condition.


Treatment
01
Medication
for stone evacuation:The likelihood of spontaneous evacuation of ureteral stones is related to the size and location of the stone. Most stones with a diameter of 4 mm or less can be passed spontaneously, while the spontaneous passage rate decreases gradually for stones with a diameter greater than 4 mm. Stones with a diameter of 10 mm or more and high-positioned ureteral stones are not easy to pass spontaneously. In clinical practice, α-blockers (tamsulosin, etc.) are commonly used to relax the smooth muscle of the ureter and reduce the tension of the ureter wall to assist stone removal therapy.

溶石:stones composed of pure uric acid can be chemically dissolved through oral medication under the guidance of a physician. Oral stone-dissolving drugs are used to dissolve uric acid stones by alkalizing the urine with alkaline sodium citrate, sodium hydrogen potassium citrate, or sodium bicarbonate. Drug-assisted lithotripsy is often more effective for kidney stones, as the volume of urine in the ureter is relatively small, resulting in poor lithotripsy efficacy for ureteral stones.

The effectiveness of drug therapy depends on multiple factors such as the composition, location, and size of the stone. At the same time, patients may experience recurrent renal colic symptoms during the treatment process. As a result, patients require repeated outpatient review follow-ups, and the efficacy is not definitive.


02
Extracorporeal Shock Wave Lithotripsy (ESWL)

In vitro lithotripsy utilizes high-energy shock waves generated by discharge, which are transmitted through water and can be directly focused on kidney/ureteral stones with the assistance of fluoroscopy. The change in tissue density between the soft kidney tissue and the hard stone causes energy to be released on the surface of the stone, thereby breaking it down. This method isconvenient and quick,and can be completed in the outpatient department without surgery, which is favored by many stone patients。

In vitro lithotripsy is suitable for small kidney stones, but the efficacy is uncertain and affected by various factors, such as the patient's body shape, the composition of the stone, and the conditions of the ureteral stone expulsion. Large stones may even require multiple in vitro lithotripsies to achieve the desired effect.

In vitro lithotripsy is suitable for small kidney stones, but the efficacy is uncertain and affected by various factors, such as the patient's body shape, the composition of the stone, and the conditions of the ureteral stone expulsion. Large stones may even require multiple in vitro lithotripsies to achieve the desired effect.Some patients have thin ureters, and small stones cannot be excreted together, like "a thousand soldiers crossing a single log bridge", completely blocking the ureter. At this time, emergency surgery is needed to relieve the obstruction.

There are also many "contraindications" for extracorporeal lithotripsy, such as renal insufficiency, urinary tract infection, coagulation dysfunction, pregnant women, serious cardiovascular and cerebrovascular diseases and diabetes, skeletal deformity, severe obesity, etc.

In short, extracorporeal lithotripsy is a double-edged sword. Patients must undergo extracorporeal lithotripsy under the guidance of a professional urological surgeon. After lithotripsy, they should pay attention to follow-up observations and timely treatment of complications.

03
Ureteroscopic (flexible) surgery

Ureteroscopy is the most common surgical procedure for treating kidney stones, and is also known colloquially as "minimally invasive surgery." The procedure is completely performed within the body cavity, with minimal damage to surrounding organs. The surgery uses holmium laser and other tools under endoscopic visualization to break up or remove the stones, which is more effective than extracorporeal lithotripsy and is suitable for the treatment of ureteral and renal stones.

Ureteroscopy is generally applicable to the surgical treatment of middle and lower ureteral stones. Ureteroscopy is a flexible surgical instrument suitable for the treatment of high-positioned stones.For kidneystones less than 2cmvarious ureteral stones, and stones after extracorporeal shock wave therapy, ureteroscopy (flexible) surgery is recommended.

The advantages of ureteroscopy (flexible)surgery are its precise efficacy, high stone clearance rate,and few surgical procedures. Most patients can achieve a high stone clearance rate with only one treatment. Its disadvantage is that it needs to be performed under anesthesia and is invasive, with the risk of surgical complications.

04
Percutaneous nephrolithotomy
Percutaneous nephrolithotomy is commonly understood as a “hole-in-the-waist”surgery,which is a minimally invasive procedure with high technology, high skill, and high risk. The surgery requires high standards for the operator and surgical instruments. For kidney stones larger than 2cm, percutaneous nephrolithotomy is the preferred method, especially for the surgical treatment of "antler-shaped" kidney stones, which has largely replaced traditional open surgery (open surgery).
The surgery involves direct puncture into the kidney, creating a channel in the waist, which can be thick or thin, as small as a straw or as large as a penholder. The stone-crushing tools used include holmium laser, pneumatic ballistic lithotripter, and ultrasonic lithotripter. Compared with ureteroscopy, lithotripsy has higher efficiency, faster speed, and higher clearance rate, but there is a corresponding risk of damage to surrounding organs and higher risk of bleeding, and the recovery time after surgery is longer.
05
Laparoscopic/Open
Surgery If some patients have complex stones, contraindications to endoscopic surgery (ureteroscopy, percutaneous nephrolithotomy), or patients who have failed endoscopic surgery, as well as patients who require simultaneous treatment of kidney stones and ureteral or renal pelvis-ureteral junction stenosis, laparoscopic or open surgery may be considered. Compared with endoscopic surgery, laparoscopic/open surgery has a relatively longer recovery time, a higher risk of postoperative adhesion and stenosis, and a lower overall safety and reliability.


The treatment of renal calculi with retrograde intrarenal surgery (RIRS) has been widely used in China in recent years due to its minimal trauma and rapid recovery. With the development and market of disposable flexible ureteroscopes, this procedure has been further promoted and popularized.

In 2022, the "Chinese Diagnosis and Treatment Guidelines for Urology and Andrology Diseases" reached a consensus on the indications and contraindications of flexible ureteroscopy for the treatment of upper urinary tract stones:


Indications for ureteral flexible stone treatment

1.

For the treatment of kidney stones or ureteral stones less than 2 cm in size

2.

Stones that are not suitable for extracorporeal shock wave lithotripsy: stones that are difficult to locate with extracorporeal shock wave lithotripsy, X-ray negative stones, and stones that are hard and not conducive to extracorporeal shock wave therapy.

3.

For the treatment of residual stones after PCNL, ESWL

4.

Combined PCNL for complex kidney stones

5.

As an alternative treatment for kidney stones larger than 2 cm

6.

For the treatment of bilateral kidney stones less than 1.5 cm in the same period of time

7.

It is used for the treatment of special types of kidney stones, such as lower calyceal stones, intraluminal stones, horseshoe kidney with kidney stones, polycystic kidney with kidney stones, large solitary kidney stones, ureteral stones after urinary diversion, upper urinary tract stones in children, kidney stones in obese patients, and kidney stones in patients with spinal deformities.

Contraindications to Ureteroscopic (flexible) stone treatment

1.

Uncontrolled urinary tract infections

2.

Those who cannot tolerate surgery due to severe cardiopulmonary disease

3.

Uncorrected diabetes, hypertension

4.

Patients with uncontrollable systemic bleeding or coagulopathy

5.

Patients with a history of pelvic surgery and radiotherapy, with significant stenosis below the ureteral lesion and bladder contracture

6.

Patients with difficulty inserting ureteroscopy due to ureteral fixation, stenosis, and fibrosis

7.

Patients with hip joint deformity and difficulty in lithotomy position


As an important means and tool for RIRS in the treatment of urinary calculi, flexible ureteroscopy plays an important role in urological diagnosis and treatment with superior performance comparable to reusable ureteroscopes.

Vathin Single-uselectronic ureterorenoscopic catheter has been continuously upgraded,to address the pain points of clinical use, and ensures a high stoneclearance rate with its unique design, ,which basically meets most of the current clinical needs of urology, and protects urological health, and has been recognized by a number of top experts.

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